I'm trying to make it palatable with Bazel + rules_js/rules_ts and pnpm but even so still end up needing Babel and Webpack because browsers are a thing. This stack does make the build times somewhat more reasonable and actually manages to avoid too much wasted work locally/CI but boy does it take a lot of work to get done.
The time I'm investing in making a Typescript monorepo viable will pay off but only when compared to not implementing my changes and staying with TS, the comparison to simply not using the stack and using something better to solve our non-Typescript specific business problems would rather lopsided.
However I have different business goals where I can actually take some time to choose a non-TS stack...
... but unfortunately with those kind of goals/restrictions the choices aren't really there, afaik.
On the client-side, you have Flutter, which is cool enough (No JS, everything in a canvas), but I'm not Dart's biggest fan, and there's no Dart WASM target yet to be able to write in one language for both (and share types).
On the server-side, most cloud companies only support Javascript + Rust + WASM, and WASM just isn't mature enough yet where it's not a total pain to work with (I think it'll get there at some point though)
So I'm left pretty much where you are, my last and only hope is a Typescript monorepo.
It's not the JS/TS language/syntax that is the problem per-se, but all the tooling that needs to exist around it for a decent DX.
NPM, Yarn, Babel, Webpack, TSC, ESLint, Prettier, even VSCode itself all contribute to an ecosystem that is a nightmare if you are trying to do anything outside of a handful of common scenarios
Tooling like Vite, Expo, CRA all try to reduce the headaches here, but at the end of the day just end up moving the headaches up an abstraction layer, and reduce the amount of supported scenarios.
That being said, there's not much support for using those languages outside of the ecosystem. Typescript is an incredible language, and if it was possible to transpile it to a language other than Javascript, that'd be ideal for me.