Yeah its super easy to set up, but the biggest reason you would want to use it in addition to other adblocking stuff is that it works outside of browsers - you can block telemetry from your smart lights, you can stop a random app on your phone from showing you ads etc etc.

It does in theory also help block some malicious sites so you do get a bit of added security in that way. That can also be helpful if you have kids - block sites you don't want them on etc.

Personally I've also found their servers to be reasonably performant, no issues with query response times or anything like that.