There are always a lot of unsatisfying hand-wavy answers to this question just saying that high framerate video looks "off" or "like a soap opera". I'd like to point out that the biggest factor here is probably the lighting.

Cinematographers have to pick particular aperture and ISO to get the depth of field and film grain they want, so they can only really adjust exposure though shutter speed. If you double the framerate, the minimum possible shutter speed halves. Therefore (unless you are shooting outside on a sunny day) it is very likely that your shot is underexposed, and the only thing you can do about it is add more lighting. This can be both logistically complicated and technically very hard to pull off without looking unnatural, especially in scenes that are supposed to be dark and moody.