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Re:LSD-like molecules counter depession without the trip by heavyset_go on Sunday October 02, 2022 @06:25PM (#33060972)
I've written about this in the past a lot[1], but 5HT2C activation is the primary cause of suicidal ideation when starting SSRIs. Once 5HT2C is downregulated after a few weeks, the feelings and akathisia caused by 5HT2C activation dissipate, as does suicidal ideation.

5HT2C activation can be very, very uncomfortable, and can exacerbate depression, anxiety and suicidal thoughts. Downregulation results in an equilibrium where those feelings and symptoms are relieved over time, however.

[1] https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...

Re:LSD-like molecules counter depession without the trip by loceng on Monday October 03, 2022 @09:47AM (#33067447)
So your argument is, if your claim is true - and if it's true in all cases or not - that those excess, unnecessary suicides, will happen within the first "few weeks" - and then that's acceptable to you that more people kill themselves on SSRIs (etc)?

And there are other options - far better, far less harmful options do indeed exist - but the medical-pharmaceutical industrial complex hasn't made them widely known or available because getting people dependant on (due to severe withdrawal in most cases, another thing they lied about; like how it was lied about the new opiates weren't addictive to get them mass prescribed) medications that are patented allows pharma to make an increasingly large recurring revenue stream; and who cares if X% of MORE people kill themselves than otherwise would have if you're now making many $ billions per month - and as a doctor all you need to do to "help" someone, and the only competency and knowledge you need, the most shallow complexity you need to understand, is to write a prescription for someone?

And then the other side of the coin is the increased homicide, and the responsibility that people they should take on if they want these medications available - on top of being in part responsible for the increased suicides - are all of the mass shooting deaths; let alone the increased ideology and antisocial behaviour we have in society could arguably be heavily influenced by these medications as well, and the widespread harm that causes to society.