Both on my main machine at home and in the office, I have a 32" 2560*1440 screen and a 24ish 1080p (they work out more it is the same pixel pitch) beside it, which I often effectively use as three portrait screens, sometimes using FancyZones so that the divide on the 32 isn't right in the middle. The setup is a bit tall when sat thought, potentially causing neck strain, but I tend to use the standing desk in up position so that isn't an issue. Tall screens are much nicer than landscape IMO.