My familiarity with Docker tells me this wouldn't be unreasonable on Linux, but Windows would probably be challenging if not impossible. I'm much more familiar with Linux so take that with a grain of salt.

I agree that I'd like to be able to do this without having to reboot and set things up before starting to mine/render.

It's on our roadmap to expand support to other systems such as Windows.

May I ask why using a thumb drive is a deal breaker? Typically the setup for our software only takes around 15 minutes to complete, and we can have someone from our support team help walk you through it.

Its having to shutdown, and having to boot into another OS. That's fine if you're targeting a mining rig, but for a home pc, you can't do anything else with the machine. Hence the deal breaker.

WSL2 only supports Nvidia and, specifically, CUDA for rendering... not OptiX.