Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons...
by stoneglyph on Tuesday September 13, 2022 @02:37PM
(#32828476)
Can you lead us to this preponderance of evidence that is out there?
Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons...
by importantbrian on Tuesday September 13, 2022 @03:24PM
(#32829082)
Sure. I'm not going to do a full lit review for you. You can search PubMed and do that on your own if you like. But here are a few good ones.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556631/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553028/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513403/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162901/
https://pubmed.ncbi.nlm.nih.gov/35901091/
https://pubmed.ncbi.nlm.nih.gov/35891173/
https://pubmed.ncbi.nlm.nih.gov/35891151/
https://pubmed.ncbi.nlm.nih.gov/35855494/
https://pubmed.ncbi.nlm.nih.gov/35821984/
https://www.covid-datascience.com/ also has some helpful discussions of this stuff if you don't want to have to dig through a bunch of studies.
In the absence of a large enough RCT we're left with observational studies and there are a ton of these now. The observational data shows a large mortality benefit in the vaccinated population and I'm not aware of a single observational study that shows the opposite, but I suppose there could be one out there that I have missed.
The preponderance of the evidence is pretty strongly in favor of the vaccinated population experiencing lower mortality than the unvaccinated population.