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A comment on Pre-exposure to mRNA-LNP inhibits adaptive immune responses in mice. Parent comment

Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons... by peyton on Tuesday September 13, 2022 @10:33AM (#32824780)
It took only 12 mice to find unexpected effects? How was the vaccine tested again?
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Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons... by yojo on Tuesday September 13, 2022 @10:44AM (#32824928)
You’d be amazed at the number of unexpected effects I could find studying just a single mouse!

Having a small number data points means that a single outlier can impact your results. And since “no results” typically doesn’t get published, the rare events end up disproportionately represented in journals.

The smaller the sample size, the more likely the “effect” you’re seeing is just random chance.

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Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons... by Sohcahtoa82 on Tuesday September 13, 2022 @10:35AM (#32824806)
> It took only 12

That's a very small sample size.

Also, it's mice.

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