Pre-exposure to mRNA-LNP inhibits adaptive immune responses in mice

Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons... by AlphaOne1 on Tuesday September 13, 2022 @10:33AM (#32824777)

I always said that the public health official must be absolutely certain they that all of the vaccines they were pushing are as safe and effective as they claimed before even considering mandating them. We now know they were wrong about at least one of them: the J&J vaccine is no longer being offered in my health system both because it's questionable safety profile and the fact that it is not as effective. Once we start preventing children from entering schools and removing people from their jobs (some with decades of experience) for not wanting to take a vaccine, the burden of proof is on the health officials to prove they are right. We also must remember that these measures have second order effects. I fear by abusing the trust the public had in physicians, public health officials have cause possibly permanent damage to the trust the average citizen has for the health community (this is especially pronounced among the underserved community).

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Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons... by pas on Tuesday September 13, 2022 @12:13PM (#32826265)

public health is about trade offs.

a fast spreading pandemic vs. this or that public health measure.

the damage to the public health community is done not because of things like operation warpspeed, but because of the realpolitik of WHO, China, Trump, etc.

responsible participants have to take the time and effort to communicate with the correct framing: as new data comes in the best course of action can change, the current best is X, based on data D1, D2, ...

of course what ended up happening was random factoids sprinkled all over various media channels linked to local/state/federal/global decisions/recommendations.

government agencies are absolutely not up to the task of doing responsible communication to the public in this day and age.

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Re:Pre-exposure to mRNA-LNP inhibits adaptive immune respons... by chiefalchemist on Tuesday September 13, 2022 @11:09AM (#32825295)

> and the fact that it is not as effective.

Well, none delivered as promised. We went from "this will do it..." to "...get your booster boosted...and boosted..."

I get it. It's difficult to say. That's the true nature of science. The problem is, that level of honesty and transparency was completely abandoned. Instead we got "it's a pandemic of the unvaccinated" which was yet another hyperbolic lie. Instead we got Fauci suggesting "wear two masks" instead of coming clean (i.e., those disposable masks didn't have any science to support their effectiveness. That is, they're useless*).

These are not opinions. These are facts. Yet we're in collective mass denial??

*Why didn't we already know this? And why isn't anyone asking why that was?

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