I highly recommend yunohost. I am using it since a few years, after a lot of years of maintaining my own "classic" mail + web server by hand [1].

I deploy it in an unprivileged LXC container [2] and went through several upgrades already. It really worked great for me.

[1] https://benou.fr/www/ben/14-years-of-self-hosting.html [2] https://github.com/bganne/yunohost