Joke aside, even for regular flight crews and passengers, it is a subject of concerns [1].

[1] https://pubmed.ncbi.nlm.nih.gov/11603132/

The idea of how they recycle drinking water is also of high concern to me personally... What if the equipment breaks or underperforms?

People constantly act as if science and technology is flawless in execution, but in reality it rarely is.

There is also space radiation and other factors that can easily affect bio organisms, without any way of knowing what happened here on earth. COmpared to the ideals of Star Trek, we are still vastly primitive in terms of understanding space... Makes me kinda sad how much safety needs to be risked just to explore the outer bounds.

You're putting the cart before the horse. Exploration is cool BECAUSE it's risky. If it were a walk in the park it would just be data entry.