Not sure, but I have a friend who has plenty of experience with psychedelics, and he just had his first session of psychedelic therapy with ketamine (done by a medical professional trained to do it). After the session he said it was very different to anything he had done before and that he felt he made a ton of progress.

My guess is that the intention that you set before “the trip”, really impacts the experience and hence the results. As well as having a professional guide/sitter that knows how to guide you and create a therapeutic setting.