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Re:Cannabis legalization decreases stock market value of maj... by heavyset_go on Friday September 02, 2022 @05:03PM (#32695693)
Dissociatives seem to be in their own class when it comes to addiction, and I wouldn't compare them with your classic psychedelics that work at 5HT2A on that metric. A lot of people get addicted to dissociatives like DXM where you don't that kind of dependence and abuse with most 5HT2A agonists.

Many dissociatives also inhibit dopamine and norepinephrine transport, or induce their release, which can have rewarding and addictive results on their own.

Re:Cannabis legalization decreases stock market value of maj... by nvrspyx on Friday September 02, 2022 @05:37PM (#32696002)
I agree, it wasn't a great comparison. I didn't want to get too into the weeds on specifics since I figured the average person would lump them all under "psychedelics" or "hallucinogens". I just wanted to point out that the activation of opioid systems may be a contributor in its more addictive nature, but it's certainly not the only factor in its addictive potential. Especially so since those dissociatives that activate dopamine or opioid systems tends to be more addictive than their more selective counterparts.