There’s still sound card with programmable DSP, quite often used to replicate high end effects. They cost a lot - and every plug-in are specialized to a brand. Still quite useful because the quality of those are very high, and don’t impact the recording process.

Or there’s still some “generic” box (I mean that you can program yourself) like the Symbolic Sound Kyma Capybara. They’re quite niche thought, like modular synth.