Last time I did audio, installing ASIO4ALL was essential.
Or get an external MIDI clock like the E-RM Multiclock and never bother about MIDI latency issues. Audio is completely fine, 30-50μs of latency won't ever be perceptible to humans, the latency of MIDI will.
In particular, the first readily available set of benchmark results I was able to find[1] suggest the difference in audio (not MIDI) latency between the lowest-latency PCIe cards and the listed USB devices (RME Fireface UFX+ USB3 and RME Babyface Pro [USB2]) is under a millisecond.
While I couldn't find similar results for MIDI I/O, it seems unlikely that either of these USB devices' MIDI interfaces would introduce an order of magnitude more latency than their audio counterparts.
[1] https://gearspace.com/board/showpost.php?p=15796206&postcoun...
This may be true but I've never had latency issues with USB soundcards. Right now I have a Line6 Helix Floor unit that I use to play guitar with. I can route the audio through the Helix effects, into Logic and back to Helix for more post-processing and have no latency problems.
I have had other brands and models and none introduced perceivable latency.
I don't use MIDI but I doubt it requires less latency than live guitar playing.
I had a PCIe soundcard a few years ago that made it almost impossible to get rid of ground hum though.