I find shifting extremely comfortable, but not quite to the extent as the author of this post. Like the author, I use thumb keys on the opposite hand to make the other hand start typing symbols. For example, I press the key below V with my left hand, and then home row on the right hand "jkl;" becomes "({})". (Actually, the whole side becomes symbols. I use the characters below the numbers to type the shifted symbol there, so qwer is !@#$, though on the other side, I don't duplicate the parentheses and instead have `~ below 9 and 0.)

Overall, I find that this is ridiculously comfortable to use.

I suffered from mild wrist pain when typing on standard keyboards, mostly because my pinky had to do so much work for programming (and pressing backspace, kill the default position of that key with fire), and the Ergodox helped me a lot.

One thing I'll note, when I moved from Ergodox to Moonlander, I lost the 1.5U key next to the h/n keys (heh). I used to use that as backspace, but moved it to my left thumb. When you're backspacing an entire word (not something I do in Emacs, but something you have to do in the web browser), the up/down/up/down/up/down motion isn't as fast with your thumb as it is with your pointer finger. OS X users probably don't have this problem, as C-w isn't "close window" there like it is on Windows.