I use NextDNS but I don't use it for adblock because if it breaks a website (which happens) I need a quick way around it that isn't a DNS change. I suppose I could use another browser that uses DNS over HTTPS via Cloudflare but I've chosen Firefox and uBlock origin. I use NextDNS to block actual websites like Twitter, Reddit and occasionally HN. It is nice to support a company that provides configurable DNS.