Tangentially related, I came up with something atrocious last night.

If you install pex with pipx (or put pex in $PATH another way), you can declare your python script dependencies in the shebang line, like:

  #!/usr/bin/env pex requests==2.28.1 other_dep=1.2.3 --exe

  import requests

  def main():
    ...

Then, you can `chmod +x` your script and call it with "--" between the script name and your arguments, if any:

  ./main.py -- arg1 arg2

Requests will be installed the first time you run it, then pex should use its cache for subsequent invocations.

I wonder if anyone's done this in earnest?