I use OPNsense router, ULAs for my devices that need a static local ip. I also host many services over ipv6 with dynamic prefixes by using a DDNS client that scans for ipv6 prefix changes and updates my dns. OPNsense can automatically adjust firewall rules as prefix changes, but your hosted services cannot use ipv6 "privacy addresses".

For local lan services I make a dns entry in my router pointing to the ULA. I have had no issues but it took awhile to figure everything out. I host matrix chat and many other services using ipv6 without issues. YMMV.