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A comment on The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene. Parent comment

Re:The mitochondrial NAD+ transporter SLC25A51 is a fasting-... by zamalek on Monday August 08, 2022 @08:21AM (#32384614)
NAD supplementation is a contested area of research, and there are many studies showing that it doesn't achieve anything useful. Further, NAD supplementation puts stress on the methylation cycle and given that you have a 10-25% chance of an MTHFR mutation (depending on your demographic) you should be very careful with NAD supplementation.
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Re:The mitochondrial NAD+ transporter SLC25A51 is a fasting-... by motive on Monday August 08, 2022 @08:44AM (#32384766)
Can you elaborate on the MTHFR mutation? I did supplementation in the past with similar results to the above commenter.
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Re:The mitochondrial NAD+ transporter SLC25A51 is a fasting-... by zamalek on Monday August 08, 2022 @02:01PM (#32388840)
It's a pretty common mutation that severely inhibits (depending on how many of the genes are mutated) methylation of folate in the liver. This is an important source of methyl groups for chemical processes, such as those that include NAD.

There's plenty more on Google, including the interaction between an MTHFR mutation and NAD supplementation.

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Re:The mitochondrial NAD+ transporter SLC25A51 is a fasting-... by valarauko on Monday August 08, 2022 @03:35PM (#32390010)
> MTHFR mutation

I'm a geneticist and I still read that as a curse word ...

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