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Re:Microdosing with psilocybin mushrooms: a double-blind pla... by jerojero on Saturday August 06, 2022 @11:14AM (#32368820)
As far as I know experiments of CBT + psychedelics have shown very promising results for treating PTSD and certain kinds of depression, specially in people that are about to die and need to come to terms with that.

These are not microdosing experiments though. The usual way it is handled is that you get a few weeks of CBT then you get half a dose and the following week you get a full dose followed by more weeks of CBT. There is no placebo effect here that's possible because, well, it is impossible for someone to believe they have taken a full dose of pscychodelic drugs and not feel anything. But you still have a control in this case because you have a group that goes through CBT and another group that goes through CBT + drugs.

In fact, from these studies there have been very little "bad trips", mostly I guess because you have the half-dose session and then the full dose session in a very controlled environment and so on. These experiments are obviously done quite responsibly.

So I think you're mixing things up a little bit and I would suggest doing a little more research in the topic. Psychodelic therapy, at least the kind that is being explored seriously is not really done through microdosing.

Re:Microdosing with psilocybin mushrooms: a double-blind pla... by TaylorAlexander on Saturday August 06, 2022 @12:51PM (#32369647)
Just a small note but my understanding is that “CBT” aka cognitive behavioral therapy is a specific form of therapy, while most research around psychedelic assisted therapy centers around traditional talk therapy rather than a more specific technique.
Re:Microdosing with psilocybin mushrooms: a double-blind pla... by tonyarkles on Saturday August 06, 2022 @12:12PM (#32369308)
> There is no placebo effect here that's possible because, well, it is impossible for someone to believe they have taken a full dose of pscychodelic drugs and not feel anything.

From what I recall, a low dose of methylphenidate is used as a control in many studies because it has some of the same side effects without the trip. For psychedelic-naive people who don’t really know what to expect, I could see it being an ok control. Once you’ve experienced a single high-dose trip though… yeah… you’re never going to trick someone with it.

Re:Microdosing with psilocybin mushrooms: a double-blind pla... by Enginerrrd on Sunday August 07, 2022 @12:40AM (#32373951)
Just because you know for sure you got the drug DOES NOT mean "no placebo effect is possible" (!)

That just means you can't possibly have a proper control. BIG difference.