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Re:The high-stakes race to engineer new psychedelic drugs by LocalH on Wednesday August 03, 2022 @08:39AM (#32330886)
N,N-DMT is my preferred psychedelic when my intent is a strong, "reset" trip. It's given me the absolute highest amount of focus control and seems to diminish the effects of my dopamine deficiency almost entirely for the better part of a couple of months, and the positive effects are still very slow to fade from there. Even today, three years after my last deep DMT trip, I find I still pull personal philosophy from it that guide me in the direction of kindness and warmth towards others.

Especially for such a short duration in consensus time (my trip was about 45 minutes, a bit on the long side but again I smoked a cigarette directly before consuming DMT, which I understand has MAOI properties and thus can extend the duration of DMT), DMT is one of the most powerful substances known to mankind. Perhaps 5-MeO-DMT might be more powerful, but there is physical risk involved there in such a way that isn't present with N,N-DMT.

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