Re:The high-stakes race to engineer new psychedelic drugs
by scythe on Tuesday August 02, 2022 @03:36PM
(#32323268)
>the liability of visual or auditory hallucinations.
The visual/audio effects aren't what gets you on a trip, though. It's the headspace, the distortion of "automatic self-recognition", and to some extent, the role of the crucial 5-ht2a receptor in the sleep-wake cycle: all 5-ht2a antagonists are soporific, and almost all psychedelics produce insomnia as a side effect. A bad trip leading to worse after-effects practically always proceeds through a sleepless night.
The visual/audio effects aren't what gets you on a trip, though. It's the headspace, the distortion of "automatic self-recognition", and to some extent, the role of the crucial 5-ht2a receptor in the sleep-wake cycle: all 5-ht2a antagonists are soporific, and almost all psychedelics produce insomnia as a side effect. A bad trip leading to worse after-effects practically always proceeds through a sleepless night.