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Re:The high-stakes race to engineer new psychedelic drugs by WalterSear on Tuesday August 02, 2022 @02:32PM (#32322558)
> The whole transformative experience is the "trip" itself.

IMHE, it's not, at least in regards to (racemic) ketamine and depression. The benefit doesn't appear until ~24 hours later, and the effect scales with dosage, but not trip intensity or outcome.

I found taking it almost unpleasant at times, but the subsequent effects uniformly profound. Unfortunately, I developed a rare health issue, or I'd still be taking it.

Re:The high-stakes race to engineer new psychedelic drugs by debenedictis on Tuesday August 02, 2022 @06:44PM (#32325232)
I too developed a rare health issue, OABSS.

"In our study, OABSS (overactive bladder symptom score) significantly increased with the combined use of ketamine and marijuana (P = 0.016). Cannabinoids are the active components of marijuana, and select cannabinoid receptors, CB1 and CB2, have been identified in the human detrusor and urothelium."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510790/