I'd kind of like to try Ruby on Rails but python was my first language and I was very, very green when I first tried to make a website so Django was a natural choice. It's served me well. I think remix.run is a pretty great framework, all things considered. You could always use Django or RoR to manage the database and use Prisma to inspect the schema. There are some downsides to that (you have to mess with bcrypt to get passwords to work the same on the node and python side), but might be a good compromise.