Re:AlphaFold reveals the structure of the protein universe
by e_i_pi_2 on Thursday July 28, 2022 @05:51PM
(#32270527)
https://alphafold.ebi.ac.uk/entry/W6KDG8
The ribbon shape for GFP is a very cool barrel thing
Re:AlphaFold reveals the structure of the protein universe
by flobosg on Thursday July 28, 2022 @06:30PM
(#32270830)
One of my favorites are some antifreeze proteins:
* https://www.rcsb.org/structure/1m8n
* https://iiif.elifesciences.org/lax/05142%2Felife-05142-fig1-...
Some proteins have 3D structures that look like abstract art only because we don't have an intuitive understanding of what shape and amino acids are necessary to convert chemical A to chemical B, which is the main purpose of many enzymes in the body. If you look at structural proteins or motor proteins, on the other hand, their function is clear from their shape.
There are a lot of other things you can do with the shape. If it has a pore, you can estimate the size and type of small molecule that could travel through it. You can estimate whether a binding site is accessible to the environment around it. You can determine if it forms a multimer or exists as a single unit. You can see if protein A and protein B have drastically different shapes given similar sequences, which might have implications for its druggability or understanding its function.