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A comment on AlphaFold reveals the structure of the protein universe. Parent comment

Re:AlphaFold reveals the structure of the protein universe by lucidrains on Thursday July 28, 2022 @12:15PM (#32266387)
To add to this, the deep learning field has already moved on towards MSA-less structure prediction. None of this would be possible without building on top of the work open sourced by Deepmind.

https://www.biorxiv.org/content/10.1101/2022.07.21.500999v1 https://www.biorxiv.org/content/10.1101/2022.07.20.500902v1

To be overly dismissive is to lack imagination.

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Re:AlphaFold reveals the structure of the protein universe by tomp on Thursday July 28, 2022 @05:43PM (#32270456)
How do we know these "MSA-less" models aren't cheating (i.e. learning all MSAs implicitly from their training data)? If they are, they would similarly fail on any "novel" AA sequence (i.e. one without known/learned MSAs)
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