Re:Fourth patient seemingly cured of HIV
by hn_throwaway_99 on Wednesday July 27, 2022 @02:00PM
(#32254048)
> But maybe additional confirmation that this pathway really works will help spur research into a way to replicate the same effect, without requiring the full bone marrow transplant process?
Doubtful. It's been known for a long time that the CCR5-delta 32 mutation conveys HIV resistance because it results in a different CCR5 coreceptor which HIV uses to enter white blood cells (this is the whole reason the bone marrow donor was selected in the first place).
Thus, the bone marrow transplant process works because now ALL of this patient's cells have that different, resistant CCR5 coreceptor. Hard to imagine a way to replicate this process without some method that results in all new white blood cells being generated like this.
Doubtful. It's been known for a long time that the CCR5-delta 32 mutation conveys HIV resistance because it results in a different CCR5 coreceptor which HIV uses to enter white blood cells (this is the whole reason the bone marrow donor was selected in the first place).
Thus, the bone marrow transplant process works because now ALL of this patient's cells have that different, resistant CCR5 coreceptor. Hard to imagine a way to replicate this process without some method that results in all new white blood cells being generated like this.