Re:Whole Genome Sequencing
by henearkr on Monday July 25, 2022 @11:51PM
(#32234050)
Ok, thank you!
So, this means there is hope for getting the data required for a full DNA restoration:
- bases near the telomeres, difficult to get (i.e. difficult to locate) with standard sequencing, can be sequenced (and located) with long-sequence sequencing (but this kind of GWS cheap service doesn't use long-sequencing right?)
- for bases around centromeres, do we assume that they are surrounded by a sea of nothingness, and that relying on a unique reference genome's centromere is enough? Isn't that risky, are we really sure that individual variations do not matter for centromeres?
My aim is to imagine a future where any defects, including centromeres, could be fixed, if necessary by regenerating whole chromosomes. Using data gathered now and safely stored.
So, this means there is hope for getting the data required for a full DNA restoration:
- bases near the telomeres, difficult to get (i.e. difficult to locate) with standard sequencing, can be sequenced (and located) with long-sequence sequencing (but this kind of GWS cheap service doesn't use long-sequencing right?)
- for bases around centromeres, do we assume that they are surrounded by a sea of nothingness, and that relying on a unique reference genome's centromere is enough? Isn't that risky, are we really sure that individual variations do not matter for centromeres?
My aim is to imagine a future where any defects, including centromeres, could be fixed, if necessary by regenerating whole chromosomes. Using data gathered now and safely stored.