Fable is pretty nice to work with. Writing bindings is fairly trivial given typescripts influence on the front-end library landscape, and you can just yolo call things dynamically if you want.

Here's a small gist where I use fable-py to use the python prettymaps project that was posted a week ago on HN: https://gist.github.com/Banashek/1cc3d8435843bcff230906fb037...