Literally nobody does that. That riots anticheat driver might interfere with your incredibly niche use case is fundamentally not a very compelling argument.

Besides, Windows LPEs are a dime a dozen anyway.

Accounts are not a good separation of context already, let alone privilege escalation exploits.

If you’re concerned about one use affecting the other you’re much better off dual-booting two Windows installations, both using BitLocker. They’d use separate keys and AES-XTS means there’s tamper protection as well. One partition could, at worst, destroy the other.