The Dylan language (witch had Lisp syntax at first)probebly had one of the early macro-systems in a language with syntax. Its ok to work with but much harder then a normal lisp.

One of the designers of Dylan tried to push this in his new language called PLOT (Programming Language for Old Timers). It has pythonic syntax and provids a full powerd macro-system. Unfortently there is no implmentation of PLOT just a discription: http://users.rcn.com/david-moon/PLOT/