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A comment on Blue Zones, where people reach age 100 at 10 times greater rates. Parent comment

Re:Blue Zones, where people reach age 100 at 10 times greate... by orangepurple on Tuesday July 19, 2022 @06:21AM (#32149628)
To expand upon this, Cholesterol is wrapped in lipoprotein, and pathogenesis is caused by malfunction of lipoproteins due to proximal oxidative and inflammatory effects upon them.
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Re:Blue Zones, where people reach age 100 at 10 times greate... by tpush on Tuesday July 19, 2022 @09:59AM (#32151539)
> [...] due to proximal oxidative and inflammatory effects upon them.

No, this is not true.

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Re:Blue Zones, where people reach age 100 at 10 times greate... by orangepurple on Tuesday July 19, 2022 @10:15AM (#32151790)
It absolutely is true for many reasons; one of them is uptake of ox-LDL by macrophage and their conversion into foam cells.

More info: https://www.ncbi.nlm.nih.gov/books/NBK326741/

Additionally, ApoB is an excellent biomarker of cardiovascular health risk.

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Re:Blue Zones, where people reach age 100 at 10 times greate... by tpush on Tuesday July 19, 2022 @10:54AM (#32152393)
I agree with ApoB being the marker for CVD risk. What I'm disagreeing with is the statement that pathogenesis is caused by inflammation and/or oxidization; instead I'd say it's the number of particles that's the primary cause, with the rest of the mechanism following.

Might just be semantic quibbling, though.

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Re:Blue Zones, where people reach age 100 at 10 times greate... by kelp on Tuesday July 19, 2022 @07:47AM (#32150203)
So what’s the cause of high cholesterol and how do you lower it?
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Re:Blue Zones, where people reach age 100 at 10 times greate... by theNJR on Tuesday July 19, 2022 @09:12AM (#32150957)
Buckle up

https://peterattiamd.com/why-there-is-no-bad-or-good-cholest...

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Re:Blue Zones, where people reach age 100 at 10 times greate... by justin66 on Tuesday July 19, 2022 @09:51AM (#32151413)
https://www.mayoclinic.org/diseases-conditions/high-blood-ch...
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