How much botox is produced per year: 800 million units [1] = 0.04 grams
Average cost per injection is $466 [3]
Allergan’s $2.8 billion Botox empire (2017), on track to grow to $4 billion by 2020 [4]
[1] https://www.brightnewme.co.uk/want-to-know-what-its-like-ins...
[2] a unit is 5.0 x 10 power -11 grams: https://toxedfoundation.org/botulinum-toxin-and-botox/
[3] https://www.plasticsurgery.org/cosmetic-procedures/botulinum...
[4] https://www.bloomberg.com/news/features/2017-10-26/inside-fo...
In some cases the half lives of the isotopes are so short they literally have to be produced on demand at a facility nearby, which usually means they can only be produced/used by facilities with their own equipment for producing them, or they are colocated on some sort of larger campus where they happen to have a suitable isotope producing accelerator as their neighbour.
Fluorine-18 is used in certain kinds of PET scans for cancer imaging, and has a half life of 109 minutes! https://en.wikipedia.org/wiki/Fluorine-18
Technetium-99m is one of the most commonly used radioisotopes for medical imaging and has a half life of just over 6 hours https://en.wikipedia.org/wiki/Technetium-99m so the usual mechanism is to ship the material that decays into Technetium-99m because the Molybdenum-99 parent isotope has a half life of 66 hours so lives long enough you can actually ship usable amounts around. So while this one is obviously not a low yield isotope, it really shows how the half life of the isotope can be worked around to make an an isotope a useful product.
Its a little hard to give simple numbers for a lot of these since they get measured by "activity" in Becquerels (Bq) as that's the useful metric based on how they get used, so giving "mass" would involve a lot of math and some guesses based on how efficient supply chains are (since you might produce twice as much and just "eat the difference" letting it decay if you have no other good way to get it to the user faster) but its a very fascinating industry.
Theres some fascinating information about how this sort of stuff gets made https://www-pub.iaea.org/MTCD/publications/PDF/te_1340_web.p... if you want to find out just how "fiddly" it can be to do chemistry with elements that might just decide to change what they are while you're working with them.
Most of the synthetic elements (like technetium, it's in the name) probably have similar or far lower yields to tritium since they all are produced by transmutation and that requires monstrous amounts of energy.
Not an element, botulinum toxin has billions of doses made, but the total production is well under a gram.
"Whats your annual yield?"
"100 grams...."
I wonder if there are other elements being produced and sold that have such low yearly yields. Bonus points if they are super expensive.