Absolutely. I've had my Model Y for about 1.5 years (14,500 miles). Recently, I've had to replace the rear tires due to slow pressure loss. Supporting 5,000 pounds certainly increases wear and tear; alas, they don't come cheap [0].

At least the "run-flat" design is worth it for long road trips, the ability to re-inflate, and increased storage space.

[0] https://tsportline.com/products/continental-procontact-rx-25...