Replacing 1 cashier/bagger with 1 self-checkout station is definitely slower.
Replacing 1 cashier/bagger with 10 self-checkout stations with 2 attendants? That'll probably be faster, especially once majority of the shoppers get used to the new system.
The other big speed enhancement is memorization of common PLUs. Seeing bananas and just knowing the code (4011 or 94011 for non organic/ organic respectively) Is a lot faster than trying to navigate through the menus. It's on the label but most people don't seem to realize that.
That said I still think it should be self check out all the way, letting one person run 6 self checkouts at midnight so I don't get caught behind the person buying two shopping carts of misc stuff while I'm just trying to grab an orange juice is miserable.