It's possible. I often use vite with multiple build targets (decoupled but with code sharing) .. this can be specified in the rollup config options but my specific build process uses two separate vite configs to resolve some chunking challenges. Everything is parallelised for dev/build in an npm script. From memory there's a bunch of conversations relating to this kind of setup in the GitHub issues.

Edit: vite allows you to specify (e.g. node specific) exclusions/globals in the config, it also allows you to specify a 'library' build if that's what you're interested in .. with named exports, etc.