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Re:EC2 to VPC: A transition worth doing. by stevefink on Thursday November 03, 2011 @03:10PM (#3193227)
The showstopper for us when it came down to whether we will use VPC or not ended up being a no due to lack of support on elastic load balancing:

http://aws.amazon.com/vpc/faqs/#E13

I will certainly revisit this topic when ELB is inevitably available for VPC based customers.

Re:EC2 to VPC: A transition worth doing. by jvoorhis on Thursday November 03, 2011 @09:24PM (#3194527)
This can be worked around by adding a gateway.

Micro instances are also unsupported within a VPC, which is also a showstopper for some.