Not really. You can do fairly large clusters, you need differently sized node pools. For example - we run apache NiFi is AKS which is a complete memory and cpu hog. We have a node pool 16cpu/64g ram for that workload which we specify a node selector. Microservices we use a different node pool. System services run on the default node pool.

If you're running Azure functions with KEDA - setup a nodepool for that with a lower cpu/memory footprint.