I will preface this by saying my mother has a PHD in neuroscience and it's application to learning and talking to her we know a lot of the details but little of the complexity's in how the brain functions. Anyway, several years ago I was riding on home from school and saw a bird out the window. Out of boredom and curiosity I just started overlaying everything I know about birds and flight. Everything from it's bone structure to the aerodynamics of flight feathers etc. I blacked out and by the time I was aware again we 10 - 15 minutes had gone by.

I assumed it was probably a good idea to never do that again, but I have a incredibly detailed memory of what I pictured so there is a pull to try it again. My point is I think you can overstress your mind and like overclocking a CPU it becomes less stable as you do so. Our minds are a complex balance of chemical signals which has real limits. I try to get enough sleep and take care of the wetware because I think it's less stable than you might assume. Rest and good food are the basics, but so is balancing how you use your mind and trying to avoid unbalanced behavior.

I have gone all out 12 hour days for long periods, but they seem to lead directly to burnout and depression. Yet, if I don't work really hard after a few months I start feeling useless and slow, so I don't think steady state is the best long term idea. My guess is finding a good cycle where I avoid burn out and feeling useless for long periods but I have periods of extreme activity and rest is my best long term balance. However, I have no idea how this relates to my inner biochemistry.