Yes, with one key difference: the Brexit campaigners insisted that the UK was being tyrannized and forced to implement policies set in Brussels by the EU (despite having full political representation in making those policy decisions), whereas Scotland is ultimately under UK control -- large elements of public policy are reserved for Westminster, which means control by a succession of governments Scotland hasn't voted for since 1955.

(The first part of this is a side-effect of UK governments since the late 1980s blaming their own unpopular public policies on the EU, aided and abetted by certain elements of the British media who made bank by painting the EU as some kind of continental political supervillain bent on tormenting the UK, rather than a political process the UK had full participation in. One of those most prominent of those journalists being one Boris Johnson ...)