Even if your office is close enough for a regional airport you might change jobs.
Of course Eugene basically has the same problem.
Some friends recently moved to Asheville, NC, which seems to be an attractive destination these days. But it's hard for them to find affordable flights, and they end up with out of the way connections that make travel onerous. Once when I was visiting Deadwood, SD, I talked to a guy who recently moved there from Denver and travels for work. But his company doesn't want to pay the high prices to fly out of Rapid City, so he found himself driving six hours back to Denver to catch flights!
If I was considering a move to a smaller metro or a rural area, I'd need to think hard about how well I could push back against my customer's requests for travel.
I grew up in Eugene and I am just done with that much rain and, like others have mentioned, endless gray.