Comparing generic "testosterone esters" - https://en.wikipedia.org/wiki/Androgen_ester - from the fifties to "testosterone esters" from today, without knowing exactly which kind of medication was involved or how it was administered, doesn't seem like a good way to reach any kind of conclusion.
Assuming you're referring to procedures around altering one's body to resemble the opposite sex, there're no long term studies on the effects of modern drug treatments, such as lupron, especially when given to children and adolescents.
The highly ideological activists surrounding this issue have made this field a wild-west, and I fully expect in the coming years, there will be more and more similar stories coming from women in particular, who have been damaged by inappropriate hormone treatments prescribed for what turn out to have been unrelated mental health issues.
1. Berger, Luckmann (1966) The Social Construction of Reality