I'm not sure I see a huge advantage that can be obtained via tight integration that you can't get by simply clicking "Save" and then ALT-Tab-ing to your Python script/notebook/whatever and re-running it, targeted at the file you just saved. If you're feeling really feisty, see about integrating a file watch program to do it as soon as you save. It's not like the editor is going to be using a pandas layout internally it can just pass to Python without marshaling.