I have moved from a well-paid, relaxed job that made rich people even richer to a much harder one that's about making people's life better. It was the best thing I've done with my career. We have people in the company who got burned out in the software industry and rejoined just for participating in the mission. (We're patientsknowbest.com, aiming to provide all the patients all their data without hidden agendas about monetizing it.)