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Re:Ask HN: Please review my site "Smoke Signal" by huhtenberg on Wednesday October 19, 2011 @04:12PM (#3131843)
Another take on the same problem is to send an automatic reply saying

  Your email has been received.
  There are %N emails in my Inbox before yours. 
  Your email is important to me.
  The estimated wait time for the response is %M days.
  Thank you for your patience.
:)
Re:Ask HN: Please review my site "Smoke Signal" by simonsarris on Wednesday October 19, 2011 @04:23PM (#3131886)
If two people both used that automatic reply, and one of them emailed the other, it would result in the world's funniest arms race.
Re:Ask HN: Please review my site "Smoke Signal" by JoshTriplett on Wednesday October 19, 2011 @04:54PM (#3132043)
Re:Ask HN: Please review my site "Smoke Signal" by kooshball on Wednesday October 19, 2011 @04:43PM (#3131987)
The big email provides should already have loop detection. This is no different than a vacation email or an NDR.
Re:Ask HN: Please review my site "Smoke Signal" by gkoberger on Wednesday October 19, 2011 @04:43PM (#3131983)
If I ever were to get an email from anyone saying that, I guarantee I would never email them again. So incredibly annoying.
Re:Ask HN: Please review my site "Smoke Signal" by hugh3 on Wednesday October 19, 2011 @09:43PM (#3133002)
Well then, it may have served its purpose!

Seriously though, there's maybe a dozen ultra-important people in the world for whom I could tolerate a reply like that. But anyone that important really should have their secretary sorting through their email anyway.

A reply like that from someone of lower (or even equal) status would be incredibly rude.

Re:Ask HN: Please review my site "Smoke Signal" by fastfinner on Wednesday October 19, 2011 @05:37PM (#3132231)
The problem with this approach is that I would not want to auto-reply to every message, particularly not group lists or important people who expect their stuff to be read on time. I think smokesignal is a lot more subtle.