GDScript uses significant whitespace but I'd hesitate to use it and Python in the same sentence. The similarities are only superficial.

And the problem with using any language not directly supported by Godot (anything but C# and GDScript) is depending on a third party to provide language support, and keep it updated with the engine. Rust bindings look like they have effort put behind them, but who knows? The only thing you can depend on is GDScript - even C# support seems like an afterthought (although I think access to Nuget and libraries make it a better choice for application development.)