Anything by Rooster Teeth is worth a try for comedy; not to everyone's taste, but if you like the main RT podcast there is a long backlog worth listening to. Skipping back 200 episodes got me through my PhD write-up.

Any shows hosted by Joe Ressington are good for Linux news if you want down-to-earth, honest conversation. Jupiter broadcast shows may also be worth a look, but personally I find most of the hosts quite annoying and their discussions superficial.

The Economist has a good spread, I mostly stick with Babbage and "Checks and Balance".

For hipsters talking about "productivity" (ie podcaster autofellatio) using Macs and other expensive tools, check the relay.fm offerings.