Re:An Account of the Shanghai Lockdown
by Laforet on Saturday April 09, 2022 @07:42AM
(#30967169)
China had administered more than 2 billion doses of vaccines using alum based adjuvant. This combined with the very low level of prior infection is theoretically the perfect breeding ground for a different serotype of Covid. Time will tell of this turns out to be the case
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Re:An Account of the Shanghai Lockdown
by selimthegrim on Saturday April 09, 2022 @10:49AM
(#30968500)
What’s so special about the adjuvant?
Alum tends to result in Th2 response, which is not very useful against viral infection as the T cells required to clear infected cells are not sufficiently activated. A lot of antibodies will be made but an RNA virus could mutate very rapidly in response, eventually leading to a new serotype that would require a different vaccine altogether. Or worse, result in antibody enhanced disease.
Most modern vaccines made against viral diseases use specialised adjuvants to avoid this known problem.