Yes, it's possible to use Bazel w/ JS tooling. At Uber we run a 1000+ package monorepo w/ Bazel and Yarn. Someone else mentioned rules_nodejs if you want to go with the popular option that is more or less in line with the Bazel philosophy[0]. We use a project called jazelle[1] that makes some different trade-offs that lets us do some interesting things like not busting the whole world's cache when lockfile changes, and source code generation (including automatic syncing of BUILD files to package.json)

[0] https://news.ycombinator.com/item?id=30959893

[1] https://github.com/uber-web/jazelle